Cover Picture: The Synthesis of Benzofulvenes through Palladium-Catalyzed Sequential Three-Component Reactions (Adv. Synth. Catal. 23/2018)

Palladium-catalyzed paraformaldehyde insertion: a three-component synthesis of benzofurans.

An efficient procedure for 2-aroylbenzofuran preparation from 2-bromophenols, phenacyl bromides and paraformaldehyde is described. The cheap and stable paraformaldehyde served as the carbon source via an in situ formylation reaction.

Palladium(II)-catalyzed stereospecific three-component domino reactions of diyne-enones, nucleophiles, and vinyl ketones.

Synthesis of 1-methyleneindenes via palladium-catalyzed tandem reactions.

Palladium-catalyzed tandem reactions of 2-alkenylphenyl-acetylenes with CuCl2 or CuBr2 afforded 3-chloro- or 3-bromo-1-methyleneindenes in good yields; these compounds could be further elaborated via palladium-catalyzed coupling reactions.

Palladium-Catalyzed Three-Component Diaryl Sulfone Synthesis Exploiting the Sulfur Dioxide Surrogate DABSO**

play novel properties as materials. Although there are a variety of methods known for the preparation of sulfones, the majority of these processes feature associated limitations. For example, oxidation of the corresponding sulfide relies on functional-group compatibility with oxidizing agents and the availability of catalysts to promote selectivity for sulfone formation over sulfoxide formation...

Palladium-catalyzed cross-coupling reactions in total synthesis.

In studying the evolution of organic chemistry and grasping its essence, one comes quickly to the conclusion that no other type of reaction plays as large a role in shaping this domain of science than carbon-carbon bond-forming reactions. The Grignard, Diels-Alder, and Wittig reactions are but three prominent examples of such processes, and are among those which have undeniably exercised decisi...